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Research Has Proven CBD's Effectiveness
FOR TREATING SYMPTOMS OF A VARIETY OF CONDITIONS
Legalization of CBD has led to a new wave of research into the effectiveness of CBD in treating a variety of illnesses and conditions. With products flooding the market making bold claims about the miracle of CBD, how do you know what information you can trust? MCBD has assembled a research library of peer reviewed research, articles and information to share with our MCBD Community so that making a choice about your health can be a little easier.
Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System
ABSTRACT This concept was further supported by a small, single-blind, split-face study, in which a cream containing 3% Cannabis seed extract was applied twice daily to the cheeks of patients for 12 weeks. The treatment
Endocannabinoid system in systemic lupus erythematosus: First evidence for a deranged 2-arachidonoylglycerol metabolism.
ABSTRACT The endocannabinoid (eCB) system plays a key role in many physiological and pathological conditions and its dysregulation has been described in several rheumatological and autoimmune diseases. Yet, its possible alteration in systemic lupus erythematosus
CBD: FOR SLEEP AND INSOMNIA
ABSTRACT Cannabinoids attach to these cells and have various effects. As far as how they may affect sleep, some research indicates that the cannabinoid CBD may interact with specific receptors potentially affecting the sleep/wake cycle.
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis.
ABSTRACT Patients were less tolerant of CBD-rich botanical extract compared with placebo, taking on average one-third fewer capsules, and having more compliance-related protocol deviations (principally insufficient exposure), prompting identification of a per protocol (PP) analysis
Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.
ABSTRACT The results indicate that while CB receptors may have a circumstantial role in keratinocyte proliferation, they do not contribute significantly to this process. Our results show that cannabinoids inhibit keratinocyte proliferation, and therefore support
Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer
ABSTRACT By focusing the attention on hemp nonpsychoactive cannabinoids, CBD has been demonstrated to be useful in the treatment of different inflammatory ailments, including bowel diseases (e.g., Crohn’s and ulcerative colitis), neuronal diseases (e.g., Parkinson
CBD Oil for Lupus: Is it Safe? Effective? Legal?
ABSTRACT With a lack of research on CBD oil for lupus, we have to go on what we know about CBD in general and what we can understand from research into conditions with similar symptoms
The gastrointestinal tract – a central organ of cannabinoid signaling in health and disease
ABSTRACT From animal studies it was rightfully concluded that cannabinoid agonists could improve visceral pain thresholds in humans. In a previous study performed in healthy volunteers to investigate the effect of dronabinol (Δ9-THC) on colonic
Using CBD Oil for Treating Anxiety
ABSTRACT While there’s currently a lack of large-scale clinical trials testing the use of CBD oil in the treatment of anxiety, a small study published in Neuropsychopharmacology in 2011 determined that CBD may help alleviate
Evidences for the Anti-panic Actions of Cannabidiol
ABSTRACT Panic disorder (PD) is a disabling psychiatry condition that affects approximately 5% of the worldwide population. Currently, long-term selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PD; however, the common side-effect profiles
The Therapeutic Potential of Cannabis and Cannabinoids
ABSTRACT Results: Almost 62% of CBD users reported using CBD to treat a medical condition. The top three medical conditions were pain, anxiety, and depression. Almost 36% of respondents reported that CBD treats their medical
Therapeutic Use of Cannabis in Inflammatory Bowel Disease
ABSTRACT These studies show different levels of elements of the ECS in murine and human IBD models. Further delineation of mechanism of action is needed to determine whether these results are pathologic or reactive effects
Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?
ABSTRACT Experimental evidence gathered from preclinical IBD models and conducted in rodents point to a strong potential of the ECS components to serve as drug targets in inflammatory diseases of the intestine. Data suggest a
Cannabinoids as novel anti-inflammatory drugs
ABSTRACT Cannabinoids have been shown to regulate the tissue response to excessive inflammation in the colon, mediated by both dampening smooth-muscular irritation caused by inflammation and suppressing proinflammatory cytokines, thus controlling the cellular pathways leading
Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis
ABSTRACT These studies demonstrate transdermal administration of CBD has long-lasting therapeutic effects without psychoactive side-effects. Thus, use of topical CBD has potential as effective treatment of arthritic symptomatology. At present, one in five (21%) adults
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis
ABSTRACT This study showed for the first time that local CBD administration inhibited pain and peripheral sensitisation in established OA. Topical treatment with CBD reduced leukocyte trafficking and joint hyperaemia during the early stages of
Transdermal cannabidiol reduces inflammation and pain‐related behaviours in a rat model of arthritis
ABSTRACT Measurement of plasma CBD concentration provided by transdermal absorption revealed linearity with 0.6–6.2 mg/day doses. Transdermal CBD gel significantly reduced joint swelling, limb posture scores as a rating of spontaneous pain, immune cell infiltration
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
ABSTRACT The therapeutic potential of cannabidiol (CBD), the major nonpsychoactive component of cannabis, was explored in murine collagen-induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice with type II collagen (CII) in complete Freund’s
Cannabis Therapeutics and the Future of Neurology
ABSTRACT A carefully crafted survey of 339 Czech patients using oral cannabis leaves reported significant alleviations of multiple symptoms (Venderová et al., 2004), particularly those using the treatment for three or more months, with improvement
Is cannabidiol the ideal drug to treat non-motor Parkinson’s disease symptoms?
ABSTRACT Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rest tremor, postural disturbances, and rigidity. PD is also characterized by non-motor symptoms such as sleep disturbances, cognitive deficits,
Cannabinoid receptors and the regulation of bone mass
ABSTRACT Our recent studies in mice and humans suggest an important role for the endocannabinoid system in the regulation of skeletal remodelling and the consequent implications on bone mass and biomechanical function. Although the CB1
